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You should not use Desvenlafaxine if you are allergic to desvenlafaxine or venlafaxine (Effexor), or if you are being treated with methylene blue injection.

Do not use Desvenlafaxine if you are taking an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. You must wait at least 14 days after stopping an MAOI before you can take Desvenlafaxine. After you stop taking Pristiq, you must wait at least 7 days before you start taking an MAOI.

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FDA pregnancy category C. Desvenlafaxine may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Desvenlafaxine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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